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Introduction

Now let’s have a look at the introduction of the Annual Update in Intensive Care and Emergency Medicine 2021. Most diseases are expressed differently in men and women.

While nearly 80% of cases of the autoimmune disease occur in women, cancer is more frequent in men. This sexual dimorphism effect is also present in infectious diseases [1], which are one of the leading causes of mortality in the world.

In the intensive care unit (ICU), sepsis and septic shock are frequent and still have high mortality rates, reaching 45% for patients with septic shock. Patient outcomes seem to rely on different phenotypes.

Sexual dimorphism could be approached as the first step in the personalized management of septic patients. In this narrative review, we describe sex differences in infectious diseases in patients admitted to the ICU.

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